I have to say that in my experience, girls who don't respond to game do tend to be different. More logical/clear-minded, have practical mindsets, and emotionally...stable/settled. I don't think it's an accident that the most game-resistant girls I've known have been in scientific fields.
I laugh at them. I actually once said, "Are you peacocking?" to one guy, laughed and others started laughing as I walked away. I'm no so much practical and level-headed but I'm an overanalytical, logical type with a head for science.
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